South Carolina Highway 63 (SC 63) is a 28.200-mile-long (45.384 km) state highway in the U.S. state of South Carolina. The highway is designated on a north–south direction, though it is signed as and located physically on an east–west orientation, from U.S. Route 278 (US 278) in Varnville to SC 64 Business (SC 64 Bus.) in Walterboro.