St David Lewis and St Francis Xavier Church is a Roman Catholic parish church in Usk, Monmouthshire, Wales. It was built in 1847 and designed by Charles Hansom in the Gothic Revival style. The church is dedicated to two Jesuit saints, Francis Xavier and the local David Lewis, who is buried nearby. It is located on Porthycarne Street near the town centre. In 2019, a shrine in the church was dedicated to David Lewis. The church is a Grade II listed building.