About: Symplocamide A

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Symplocamide A is a newly discovered (2008) 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide that has been isolated from a marine cyanobacteria in Papua New Guinea, which has only been identified at the genus level (Symploca). Cyanobacteria, both freshwater and marine, are known as producers of diverse protease inhibitors that may be used to treat diseases, such as HIV, and some forms of cancer. Research on symplocamide A has shown that it is a strong serine protease inhibitor and has a high level of cytotoxicity to cancer cells when used in vitro. As of the time of this writing, its use as a treatment on human participants has not been done and future study will have to be done before any human testing can be commenced.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound yago:WikicatBacterialToxins yago:Agent114778436 yago:Antiviral102725367 yago:BacterialToxin115034939 yago:CausalAgent100007347 yago:Drug103247620 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:Poison115032376 yago:ProteaseInhibitor104013993 chemical compound yago:Substance100020090 yago:Toxin115034074 yago:WikicatProteaseInhibitors
rdfs:label	Symplocamide A (en)
rdfs:comment	Symplocamide A is a newly discovered (2008) 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide that has been isolated from a marine cyanobacteria in Papua New Guinea, which has only been identified at the genus level (Symploca). Cyanobacteria, both freshwater and marine, are known as producers of diverse protease inhibitors that may be used to treat diseases, such as HIV, and some forms of cancer. Research on symplocamide A has shown that it is a strong serine protease inhibitor and has a high level of cytotoxicity to cancer cells when used in vitro. As of the time of this writing, its use as a treatment on human participants has not been done and future study will have to be done before any human testing can be commenced. (en)
foaf:name	Symplocamide A (en)
name	Symplocamide A (en)
foaf:depiction
dcterms:subject	Depsipeptides Macrocycles Protease inhibitors Bacterial toxins
Wikipage page ID	31725673 (xsd:integer)
Wikipage revision ID	1038708722 (xsd:integer)
Link from a Wikipage to another Wikipage	Depsipeptides Macrocycles Lung cancer Protease inhibitor (pharmacology) HIV Protease inhibitors Cyanobacteria Cytotoxin Papua New Guinea Bacterial toxins Neuroblastoma Nuclear magnetic resonance Serine protease inhibitor Cyclodepsipeptide
sameAs	Symplocamide A Symplocamide A Symplocamide A Symplocamide A Symplocamide A Symplocamide A
dbp:wikiPageUsesTemplate	dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite
thumbnail	wiki-commons:Special:FilePath/Symplocamide_A.svg?width=300
ImageFile	Symplocamide A.svg (en)
ImageName	Symplocamide A (en)
imagesize	200 (xsd:integer)
IUPACName	N1-[-5--2-[-butan-2-yl]-15-[3-propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8--10-oxa-1,4,7,14,17-pentaazabicyclo[16.3.1]docos-12-yl]-N2-butanoyl-L-glutamamide (en)
has abstract	Symplocamide A is a newly discovered (2008) 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide that has been isolated from a marine cyanobacteria in Papua New Guinea, which has only been identified at the genus level (Symploca). Cyanobacteria, both freshwater and marine, are known as producers of diverse protease inhibitors that may be used to treat diseases, such as HIV, and some forms of cancer. Research on symplocamide A has shown that it is a strong serine protease inhibitor and has a high level of cytotoxicity to cancer cells when used in vitro. As of the time of this writing, its use as a treatment on human participants has not been done and future study will have to be done before any human testing can be commenced. (en)
prov:wasDerivedFrom	wikipedia-en:Symplocamide_A?oldid=1038708722&ns=0
page length (characters) of wiki page	4950 (xsd:nonNegativeInteger)
IUPAC name	N1-[(2S,5S,8S,11R,12S,15S,18S,21R)-5-(3-bromo-4-methoxybenzyl)-2-[(2S)-butan-2-yl]-15-[3-(carbamoylamino)propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-(propan-2-yl)-10-oxa-1,4,7,14,17-pentaazabicyclo[16.3.1]docos-12-yl]-N2-butanoyl-L-glutamamide (en)
foaf:isPrimaryTopicOf	wikipedia-en:Symplocamide_A
is Link from a Wikipage to another Wikipage of	List of compounds with carbon numbers 40–49 Symplocamide
is Wikipage redirect of	Symplocamide
is foaf:primaryTopic of	wikipedia-en:Symplocamide_A

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