About: Syntrophin

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The syntrophins are a family of five 60-kiloDalton proteins that are associated with dystrophin, the protein associated with Duchenne muscular dystrophy and Becker muscular dystrophy. The name comes from the Greek word syntrophos, meaning "companion." The five syntrophins are encoded by separate genes and are termed α, β1, β2, γ1, and γ2. Syntrophin was first identified as a dystrophin-associated protein present in the Torpedo electric organ (originally called "58K protein"). Subsequently, α-syntrophin was shown to be the predominant isoform in skeletal muscle where it is localized on the sarcolemma and enriched at the neuromuscular junction. The β-syntrophins and γ2-syntrophin are also present in skeletal muscle but also are in most other tissues. The expression of γ1-syntrophin is mostly

Attributes	Values
rdf:type	yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteins
rdfs:label	Syntrophin (en)
rdfs:comment	The syntrophins are a family of five 60-kiloDalton proteins that are associated with dystrophin, the protein associated with Duchenne muscular dystrophy and Becker muscular dystrophy. The name comes from the Greek word syntrophos, meaning "companion." The five syntrophins are encoded by separate genes and are termed α, β1, β2, γ1, and γ2. Syntrophin was first identified as a dystrophin-associated protein present in the Torpedo electric organ (originally called "58K protein"). Subsequently, α-syntrophin was shown to be the predominant isoform in skeletal muscle where it is localized on the sarcolemma and enriched at the neuromuscular junction. The β-syntrophins and γ2-syntrophin are also present in skeletal muscle but also are in most other tissues. The expression of γ1-syntrophin is mostly (en)
dcterms:subject	Protein families
Wikipage page ID	12783118 (xsd:integer)
Wikipage revision ID	1076966714 (xsd:integer)
Link from a Wikipage to another Wikipage	Becker muscular dystrophy SNTA1 dbr:Dystrophin Signal transducing adaptor protein Protein families Electric organ (biology) Gene Aquaporin Torpedo (genus) Ion channel Duchenne muscular dystrophy Nitric oxide Nitric oxide synthase PDZ domain Kinase Protein domain Isoform Protein Atomic mass unit Neuromuscular junction Sarcolemma SNTG1 Pleckstrin homology domain NOS1 SNTB2 SNTB1 SNTG2 Skeletal muscle Dystrophin-associated glycoprotein complex Signaling protein
sameAs	Syntrophin Syntrophin Syntrophin Syntrophin
dbp:wikiPageUsesTemplate	dbt:MeshName dbt:Protein-stub dbt:Reflist dbt:Muscle_tissue
has abstract	The syntrophins are a family of five 60-kiloDalton proteins that are associated with dystrophin, the protein associated with Duchenne muscular dystrophy and Becker muscular dystrophy. The name comes from the Greek word syntrophos, meaning "companion." The five syntrophins are encoded by separate genes and are termed α, β1, β2, γ1, and γ2. Syntrophin was first identified as a dystrophin-associated protein present in the Torpedo electric organ (originally called "58K protein"). Subsequently, α-syntrophin was shown to be the predominant isoform in skeletal muscle where it is localized on the sarcolemma and enriched at the neuromuscular junction. The β-syntrophins and γ2-syntrophin are also present in skeletal muscle but also are in most other tissues. The expression of γ1-syntrophin is mostly confined to brain. The syntrophins are adaptor proteins that use their multiple protein interaction domains (two pleckstrin homology domains and a PDZ domain) to localize a variety of signaling proteins (kinases, ion channels, water channels, nitric oxide synthase) to specific intracellular locations. α-Syntrophin binds to nNOS in the dystrophin-associated glycoprotein complex in skeletal muscle cells. There it produces NO upon muscle contraction leading to dilation of the arteries in the local area. (en)
gold:hypernym	Family
prov:wasDerivedFrom	wikipedia-en:Syntrophin?oldid=1076966714&ns=0
page length (characters) of wiki page	1910 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Syntrophin
is Link from a Wikipage to another Wikipage of	David S. Bredt Dystrobrevin beta Islands of Calleja Costamere Dystrobrevin alpha SNTG1 Pleckstrin homology domain SNTG2
is foaf:primaryTopic of	wikipedia-en:Syntrophin

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