State Route 16 (SR 16) is a state highway in the U.S. state of Tennessee. Its southern terminus is at the Alabama State Line, where it continues as State Route 79 (SR 79) in Alabama. From there, it continues to Winchester, where it becomes unsigned in a concurrency with U.S. Route 41A (US 41A). This concurrency lasts until its northern terminus in Williamson County, at a junction with U.S. Route 31A (US 31A).