Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome, as well as stress, anxiety and depression.
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| - Tetrahidrodeoksikortikosteron (in)
- Tetraidrodeossicorticosterone (it)
- Tetrahydrodeoxycorticosterone (en)
- Тетрагидродеоксикортикостерон (ru)
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| - Tetrahidrodeoksikortikosteron (bahasa Inggris: Tetrahydrodeoxycorticosterone, THDOC) merupakan neurosteroid yang mengikat pencerap GABA. THDOC disintesis di dalam otak dari dengan bantuan enzim 5alfa-reduktase tipe I dan 3alfa-hidroksisteroid dehidrogenase. (in)
- Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome, as well as stress, anxiety and depression. (en)
- Il tetraidrodeossicorticosterone (3α,21-diidrossi-5α-pregnan-20-one; THDOC), o più comunemente allotetraidrossicorticosterone, è un neurosteroide endogeno. È sintetizzato dall'ormone adrenale per azione di due enzimi, la e la 3α-idrossisteroide deidrogenasi. Il THDOC ha effetti sedativi, ansiolitici e anticonvulsivi.Variazioni nei livelli normali di questo steroide, in particolare durante la gravidanza e la mestruazione, possono essere coinvolte in alcuni tipi di epilessia (epilessia catameniale), come anche nelle condizioni di stress, ansia e depressione. (it)
- Тетрагидродеоксикортикостерон (THDOC) - нейростероид, синтезируемый в мозге из дезоксикортикостерона с помощью двух ферментов: 5-альфа-редуктазы I и . Сообщается о седативном, анксиолитическом и противосудорожном действии THDOC в мозге. Возможно, колебания уровней THDOC в мозге во время беременности, менструального цикла играют роль в развитии некоторых типов эпилепсии. Также предполагается участие данного нейростероида в процессах, связанных со стрессом, тревогой, депрессиями. (ru)
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| - Tetrahidrodeoksikortikosteron (bahasa Inggris: Tetrahydrodeoxycorticosterone, THDOC) merupakan neurosteroid yang mengikat pencerap GABA. THDOC disintesis di dalam otak dari dengan bantuan enzim 5alfa-reduktase tipe I dan 3alfa-hidroksisteroid dehidrogenase. (in)
- Tetrahydrodeoxycorticosterone (abbreviated as THDOC; 3α,21-dihydroxy-5α-pregnan-20-one), also referred to as allotetrahydrocorticosterone, is an endogenous neurosteroid. It is synthesized from the adrenal hormone deoxycorticosterone by the action of two enzymes, 5α-reductase type I and 3α-hydroxysteroid dehydrogenase. THDOC is a potent positive allosteric modulator of the GABAA receptor, and has sedative, anxiolytic and anticonvulsant effects. Changes in the normal levels of this steroid particularly during pregnancy and menstruation may be involved in some types of epilepsy (catamenial epilepsy) and premenstrual syndrome, as well as stress, anxiety and depression. (en)
- Il tetraidrodeossicorticosterone (3α,21-diidrossi-5α-pregnan-20-one; THDOC), o più comunemente allotetraidrossicorticosterone, è un neurosteroide endogeno. È sintetizzato dall'ormone adrenale per azione di due enzimi, la e la 3α-idrossisteroide deidrogenasi. Il THDOC ha effetti sedativi, ansiolitici e anticonvulsivi.Variazioni nei livelli normali di questo steroide, in particolare durante la gravidanza e la mestruazione, possono essere coinvolte in alcuni tipi di epilessia (epilessia catameniale), come anche nelle condizioni di stress, ansia e depressione. (it)
- Тетрагидродеоксикортикостерон (THDOC) - нейростероид, синтезируемый в мозге из дезоксикортикостерона с помощью двух ферментов: 5-альфа-редуктазы I и . Сообщается о седативном, анксиолитическом и противосудорожном действии THDOC в мозге. Возможно, колебания уровней THDOC в мозге во время беременности, менструального цикла играют роль в развитии некоторых типов эпилепсии. Также предполагается участие данного нейростероида в процессах, связанных со стрессом, тревогой, депрессиями. (ru)
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