State Highway 54 (SH 54) is a 55.2-mile (88.8 km) highway maintained by the Texas Department of Transportation (TxDOT) that runs from Interstate 10 and U.S. Route 90 in Van Horn north to US 62 and US 180 between Salt Flat and Pine Springs near Guadalupe Mountains National Park. The route, located in western Culberson County, is largely isolated passing through no cities or towns beyond Van Horn and intersecting no other highways between Van Horn and its northern terminus. Within Van Horn, the route has intersections with Business Interstate 10-D and Farm to Market Road 2185.