About: Thrombin receptor

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There are three known thrombin receptors (ThrR), termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). G-protein-coupled receptors that are responsible for the coagulation effects and responses of thrombin on cells are known as protease-activated receptors, or PARs. These receptors are members of the 7-transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Unlike most G-protein-coupled receptors, PARs are irreversibly activated by proteolytic mechanism and therefore, are strictly regulated.

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rdf:type	yago:BodyPart105220461 yago:Part109385911 yago:PhysicalEntity100001930 yago:Receptor105608868 yago:WikicatGProteinCoupledReceptors protein yago:Structure105225602 yago:Thing100002452
rdfs:label	トロンビン受容体 (ja) Thrombin receptor (en)
rdfs:comment	トロンビン受容体（トロンビンじゅようたい、英: thrombin receptor、略称: ThrR）は3種類が知られており、PAR1、PAR3、PAR4と命名されている（PARはプロテアーゼ活性化受容体（protease-activated receptor）を意味する）。これらの受容体はGタンパク質共役7回膜貫通受容体ファミリーのメンバーであるが、これらの活性化方法は独特である。セリンプロテアーゼであるトロンビンは、受容体の細胞外のN末端ドメインに結合して切断を行う。その結果、新たに形成されたN末端のSFLLRNが露出し、これがテザードリガンド（係留リガンド）として受容体の2番目の細胞外ループに結合して活性化を行う。 (ja) There are three known thrombin receptors (ThrR), termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). G-protein-coupled receptors that are responsible for the coagulation effects and responses of thrombin on cells are known as protease-activated receptors, or PARs. These receptors are members of the 7-transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Unlike most G-protein-coupled receptors, PARs are irreversibly activated by proteolytic mechanism and therefore, are strictly regulated. (en)
foaf:depiction
dcterms:subject	G protein-coupled receptors
Wikipage page ID	5895398 (xsd:integer)
Wikipage revision ID	1065038428 (xsd:integer)
Link from a Wikipage to another Wikipage	7-transmembrane Desensitization (medicine) Internalization Ligand (biochemistry) Protease-activated receptor G protein-coupled receptor Glia Kinase Receptor-mediated endocytosis Receptor (biochemistry) Smooth muscle Arrestin G protein-coupled receptors Coagulation dbr:Coagulation_factor_II_receptor dbr:Thrombin Fibroblast Sensory neuron F2RL2 Lysosome N-terminus N-terminal domain Serine protease PAR4 G protein-coupled
sameAs	Thrombin receptor Thrombin receptor Thrombin receptor Thrombin receptor Thrombin receptor
dbp:wikiPageUsesTemplate	dbt:G_protein-coupled_receptors dbt:Biochem-stub dbt:Redirect dbt:Reflist dbt:Transmembrane_receptors
thumbnail	wiki-commons:Special:FilePath/Activation_of_PAR.png?width=300
has abstract	There are three known thrombin receptors (ThrR), termed PAR1, PAR3 and PAR4 (PAR for protease-activated receptor). G-protein-coupled receptors that are responsible for the coagulation effects and responses of thrombin on cells are known as protease-activated receptors, or PARs. These receptors are members of the 7-transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Unlike most G-protein-coupled receptors, PARs are irreversibly activated by proteolytic mechanism and therefore, are strictly regulated. Thrombin is an allosteric serine protease that is an essential effector of coagulation that is produced at sites of vascular injury and plays a critical role in cellular response to blood-related diseases. It binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it. (en) トロンビン受容体（トロンビンじゅようたい、英: thrombin receptor、略称: ThrR）は3種類が知られており、PAR1、PAR3、PAR4と命名されている（PARはプロテアーゼ活性化受容体（protease-activated receptor）を意味する）。これらの受容体はGタンパク質共役7回膜貫通受容体ファミリーのメンバーであるが、これらの活性化方法は独特である。セリンプロテアーゼであるトロンビンは、受容体の細胞外のN末端ドメインに結合して切断を行う。その結果、新たに形成されたN末端のSFLLRNが露出し、これがテザードリガンド（係留リガンド）として受容体の2番目の細胞外ループに結合して活性化を行う。 (ja)
gold:hypernym	Receptors
prov:wasDerivedFrom	wikipedia-en:Thrombin_receptor?oldid=1065038428&ns=0
page length (characters) of wiki page	5454 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Thrombin_receptor
is Link from a Wikipage to another Wikipage of	Desogestrel Pharmacodynamics of progesterone Index of biochemistry articles ThrR Medroxyprogesterone acetate Protease-activated receptor THRR Dipyridamole Fibrin Multiple electrode aggregometry Thrombin receptors
is Wikipage redirect of	ThrR Thrombin receptors
is foaf:primaryTopic of	wikipedia-en:Thrombin_receptor

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