About: Tifluadom     Goto   Sponge   NotDistinct   Permalink

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Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite.

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  • Tifluadom (de)
  • Tifluadom (it)
  • Tifluadom (en)
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  • Tifluadom ist ein nicht therapeutisch genutztes Benzodiazepin-Derivat mit einem für diese Substanzklasse abnormen Wirkmechanismus. (de)
  • Il tifluadom è uno psicofarmaco appartenente alla categoria delle benzodiazepine. A differenza della maggior parte delle benzodiazepine, il tifluadom non ha attività sul recettore GABA A , ma è invece un agonista selettivo per il recettore kappa oppioide. Il farmaco ha potenti effetti analgesici, diuretici negli animali, sedativi e stimola l'appetito. Ha inoltre degli effetti sul comportamento dei ratti che possono essere contrastati con la somministrazione di Naloxone. (it)
  • Tifluadom is a benzodiazepine derivative with an unusual activity profile. Unlike most benzodiazepines, tifluadom has no activity at the GABAA receptor, but instead is a selective agonist for the κ-opioid receptor. In accordance, it has potent analgesic and diuretic effects in animals, and also has sedative effects and stimulates appetite. (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Tifluadom.svg
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  • none (en)
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IUPAC name
  • N-5-(2-Fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]thiophene-3-carboxamide (en)
KEGG
  • D02694 (en)
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