"Tighten Up" is a song by American rock band The Black Keys. It is the third track on their 2010 album Brothers and was released as the record's first single on April 23, 2010. The song has become one of the most successful Black Keys singles in the United States, being their first song to chart on the Billboard Hot 100 and reaching number one on the Alternative Songs and Rock Songs charts. Rolling Stone put the song on its list of the 15 Best Whistling Songs of All Time. At the 53rd Grammy Awards in 2011, the song won Best Rock Performance by a Duo or Group with Vocal of 2010 (the last song to receive the award), while also receiving a nomination for Best Rock Song. Musically, the song is in the key of F sharp minor.