Tip links are extracellular filaments that connect stereocilia to each other or to the kinocilium in the hair cells of the inner ear. Mechanotransduction is thought to occur at the site of the tip links, which connect to spring-gated ion channels. These channels are cation-selective transduction channels that allow potassium and calcium ions to enter the hair cell from the endolymph that bathes its apical end. When the hair cells are deflected toward the kinocilium, depolarization occurs; when deflection is away from the kinocilium, hyperpolarization occurs. The tip link is made of two different cadherin molecules, protocadherin 15 and cadherin 23. It has been found that the tip links are relatively stiff, so it is thought that there has to be something else in the hair cells that is stret
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- Tip link (en)
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| - Tip links jsou extracelulární filamenta, která ve vláskových buňkách vnitřního ucha tvoří spoje mezi jednotlivými stereocilii nebo mezi stereocilii a kinocilii. Na straně, kde jsou tip links připojeny na mechanicky řízené iontové kanály, dochází k přeměně energie pohybu (mechanického stimulu) na elektrický signál = mechanická transdukce. (cs)
- Tip links are extracellular filaments that connect stereocilia to each other or to the kinocilium in the hair cells of the inner ear. Mechanotransduction is thought to occur at the site of the tip links, which connect to spring-gated ion channels. These channels are cation-selective transduction channels that allow potassium and calcium ions to enter the hair cell from the endolymph that bathes its apical end. When the hair cells are deflected toward the kinocilium, depolarization occurs; when deflection is away from the kinocilium, hyperpolarization occurs. The tip link is made of two different cadherin molecules, protocadherin 15 and cadherin 23. It has been found that the tip links are relatively stiff, so it is thought that there has to be something else in the hair cells that is stret (en)
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| - Tip links jsou extracelulární filamenta, která ve vláskových buňkách vnitřního ucha tvoří spoje mezi jednotlivými stereocilii nebo mezi stereocilii a kinocilii. Na straně, kde jsou tip links připojeny na mechanicky řízené iontové kanály, dochází k přeměně energie pohybu (mechanického stimulu) na elektrický signál = mechanická transdukce. Tyto kanály umožňují kationtům draslíku a vápníku vstoupit do vláskových buněk z endolymfy, která omývá jejich apikální stranu. Endolymfa ductus cochlearis obsahuje mnoho draselných kationtů, díky tomu prochází kanálem do vláskové buňky ve směru koncentračního gradientu. Když se vlásková buňka ohne směrem ke kinociliu, tak dojde k depolarizaci. Při pohybu směrem od kinocilia dojde k hyperpolarizaci. Tip links se skládají z dvou různých molekul kadherinů: protokadherinu 15 a kadherinu 23. Bylo zjištěno, že tip links jsou poměrně tuhé povahy, takže ve vláskových buňkách musí existovat něco pružného, co umožňuje stereociliím pohyb tam a zpět. Existuje hypotéza, že tip links se připojují na myozin, který se pohybuje podél filament aktinu. (cs)
- Tip links are extracellular filaments that connect stereocilia to each other or to the kinocilium in the hair cells of the inner ear. Mechanotransduction is thought to occur at the site of the tip links, which connect to spring-gated ion channels. These channels are cation-selective transduction channels that allow potassium and calcium ions to enter the hair cell from the endolymph that bathes its apical end. When the hair cells are deflected toward the kinocilium, depolarization occurs; when deflection is away from the kinocilium, hyperpolarization occurs. The tip link is made of two different cadherin molecules, protocadherin 15 and cadherin 23. It has been found that the tip links are relatively stiff, so it is thought that there has to be something else in the hair cells that is stretchy which allows the stereocilia to move back and forth. It is hypothesized that the tip link is attached to the myosin motor which moves along actin filaments. (en)
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