On Thursday, September 29, 1927, an outbreak of at least 15 significant tornadoes, including three F3 tornadoes, killed at least 82 people in the Central United States, particularly in Missouri and Illinois. The outbreak affected a broad expanse of the Midwestern and Southern United States, including Oklahoma, Missouri, Arkansas, Iowa, Illinois, and Indiana. The deadliest tornado was an estimated F3 which affected portions of Greater St. Louis, killing at least 79 people and injuring at least 550 others. The tornado narrowly missed Downtown St. Louis, striking north of the central business district before crossing the Mississippi River.