About: Transforming protein RhoA

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Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of t

Attributes	Values
rdf:type	Thing Biomolecule gene Biomolecule Gene HumanGene
rdfs:label	Transforming protein RhoA (en) RHOA (uk)
rdfs:comment	Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of t (en) RHOA (англ. Ras homolog family member A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 193 амінокислот, а молекулярна маса — 21 768. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин (uk)
dcterms:subject	EC 3.6.5
Wikipage page ID	13975479 (xsd:integer)
Wikipage revision ID	1124562353 (xsd:integer)
Link from a Wikipage to another Wikipage	Protein-protein interaction MAP3K1 GEFT KTN1 Protein kinase N1 LINGO1 Low-affinity nerve growth factor receptor RICS (gene) Cofilin Gene EC 3.6.5 Transforming growth factor Actin Cyclin D1 DGKQ DIAPH1 Prenylation Small GTPase Drosophila Cell division KCNA2 Protein Ras superfamily Rho family of GTPases ARHGAP1 ARHGAP5 ARHGDIA ARHGEF11 ARHGEF12 ARHGEF3 Guanosine diphosphate Guanosine triphosphate RAP1GDS1 TRIO (gene) Growth cone CIT (gene) dbr:ROCK1 Neurotrophin ITPR1 Phospholipase A2 Reticulon 4 PKN2 PLCG1 TRPC1 Rho-associated protein kinase Uropod (immunology) Guanine nucleotide exchange factors
Link from a Wikipage to an external page	http://www.cellmigration.org/index.shtml https://web.archive.org/web/20141211173306/http:/www.cellmigration.org/index.shtml https://web.archive.org/web/20110704224546/http:/cmkb.cellmigration.org/report.cgi%3Freport=orth_overview&gene_id=387
sameAs	Transforming protein RhoA Transforming protein RhoA Transforming protein RhoA Transforming protein RhoA Transforming protein RhoA
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Div_col dbt:Div_col_end dbt:Enzymes dbt:For dbt:Infobox_gene dbt:MeshName dbt:PDB_Gallery dbt:Portal_bar dbt:Refbegin dbt:Refend dbt:Reflist dbt:Short_description dbt:Webarchive dbt:Acid_anhydride_hydrolases dbt:PDBe-KB2
date	2014-12-11 (xsd:date)
url	https://web.archive.org/web/20141211173306/http:/www.cellmigration.org/index.shtml
has abstract	Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation. (en) RHOA (англ. Ras homolog family member A) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 3-ї хромосоми. Довжина поліпептидного ланцюга білка становить 193 амінокислот, а молекулярна маса — 21 768. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у таких біологічних процесах як взаємодія хазяїн-вірус, клітинний цикл, поділ клітини. Білок має сайт для зв'язування з нуклеотидами, ГТФ, іоном магнію. Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних відростках. (uk)
prov:wasDerivedFrom	wikipedia-en:Transforming_protein_RhoA?oldid=1124562353&ns=0
page length (characters) of wiki page	45863 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Transforming_protein_RhoA
is Link from a Wikipage to another Wikipage of	MAP3K1 MEFV RhoA Cyclin-dependent kinase 5 Precision diagnostics Low-affinity nerve growth factor receptor RASIP1 Statin MiR-125

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