Transfusion-related immunomodulation (TRIM) refers to the transient depression of the immune system following transfusion of blood products. This effect has been recognized in groups of individuals who have undergone kidney transplantation or have had multiple miscarriages. Some research studies have shown that, because of this immune depression, blood transfusions increase the risk of infections and cancer recurrence. However, other studies have not shown these differences and the degree of impact transfusion has on infection and tumor recurrence is not well understood. The Blood Products Advisory Committee of the Food and Drug Administration recommends that all transfused blood products undergo leukocyte reduction in order to offset the contribution of donor white blood cells to immune s
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| - Imunomodulação relacionada à transfusão (pt)
- Transfusion-related immunomodulation (en)
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| - A imunomodulação relacionada à transfusão (TRIM, do inglês: transfusion-related immunomodulation) refere-se à depressão transitória do sistema imunológico após a transfusão de produtos sanguíneos. Este efeito foi reconhecido em grupos de indivíduos submetidos a transplante renal ou que tiveram abortos espontâneos múltiplos. Algumas pesquisas mostraram que, por causa dessa depressão imunológica, as transfusões de sangue aumentam o risco de infecções e de recorrência do câncer. No entanto, outros estudos não mostraram essas diferenças e o grau de impacto da transfusão na infecção e na recorrência do tumor não é bem compreendido. (pt)
- Transfusion-related immunomodulation (TRIM) refers to the transient depression of the immune system following transfusion of blood products. This effect has been recognized in groups of individuals who have undergone kidney transplantation or have had multiple miscarriages. Some research studies have shown that, because of this immune depression, blood transfusions increase the risk of infections and cancer recurrence. However, other studies have not shown these differences and the degree of impact transfusion has on infection and tumor recurrence is not well understood. The Blood Products Advisory Committee of the Food and Drug Administration recommends that all transfused blood products undergo leukocyte reduction in order to offset the contribution of donor white blood cells to immune s (en)
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| - Transfusion-related immunomodulation (TRIM) refers to the transient depression of the immune system following transfusion of blood products. This effect has been recognized in groups of individuals who have undergone kidney transplantation or have had multiple miscarriages. Some research studies have shown that, because of this immune depression, blood transfusions increase the risk of infections and cancer recurrence. However, other studies have not shown these differences and the degree of impact transfusion has on infection and tumor recurrence is not well understood. The Blood Products Advisory Committee of the Food and Drug Administration recommends that all transfused blood products undergo leukocyte reduction in order to offset the contribution of donor white blood cells to immune suppression. (en)
- A imunomodulação relacionada à transfusão (TRIM, do inglês: transfusion-related immunomodulation) refere-se à depressão transitória do sistema imunológico após a transfusão de produtos sanguíneos. Este efeito foi reconhecido em grupos de indivíduos submetidos a transplante renal ou que tiveram abortos espontâneos múltiplos. Algumas pesquisas mostraram que, por causa dessa depressão imunológica, as transfusões de sangue aumentam o risco de infecções e de recorrência do câncer. No entanto, outros estudos não mostraram essas diferenças e o grau de impacto da transfusão na infecção e na recorrência do tumor não é bem compreendido. (pt)
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