About: Traumatic brain injury modeling

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Traumatic brain injury modeling replicates aspects of traumatic brain injury (TBI) as a method to better understand what physically happens to the brain. Researchers use a variety of models for this process, with different models able to replicate certain aspects of TBI while also producing their own limitations.

Attributes	Values
rdfs:label	Traumatic brain injury modeling (en)
rdfs:comment	Traumatic brain injury modeling replicates aspects of traumatic brain injury (TBI) as a method to better understand what physically happens to the brain. Researchers use a variety of models for this process, with different models able to replicate certain aspects of TBI while also producing their own limitations. (en)
dcterms:subject	Neurotrauma
Wikipage page ID	41121515 (xsd:integer)
Wikipage revision ID	1064795444 (xsd:integer)
Link from a Wikipage to another Wikipage	Neurotrauma Deformation (mechanics) Cytoskeleton In vitro In vivo Nanotechnology Peripheral Nervous System Nanomedicine Apoptosis Stress (mechanics) Compression (physics) Haemodynamic response Strain (chemistry) Cell membranes Central Nervous System Traumatic brain injury Cortical layer Cytokines Glial scar Wave propagation Astrocytes Elastic deformation Tension (physics) Mitosis Stochastic Eulerian Lagrangian method Growth factor Intensity (physics) Nanoparticles Cerebrospinal fluid Finite element method dbr:Diffuse_Axonal_Injury dbr:Tropic_factors
Link from a Wikipage to an external page	http://www.jove.com/video/50928/stretch-brain-microvascular-endothelial-cells-cend-as-an-vitro
sameAs	Traumatic brain injury modeling Traumatic brain injury modeling Traumatic brain injury modeling
dbp:wikiPageUsesTemplate	dbt:Cite_journal dbt:Orphan dbt:Refbegin dbt:Refend dbt:Reflist
has abstract	Traumatic brain injury modeling replicates aspects of traumatic brain injury (TBI) as a method to better understand what physically happens to the brain. Researchers use a variety of models for this process, with different models able to replicate certain aspects of TBI while also producing their own limitations. An estimated 1.7 million cases of TBI occur per year, not taking into account the lasting affects that TBI may cause. TBI is also reported as a contributing factor in about 30% of all injury related death. Given how prevalent TBI is, preventing or minimizing its effects would benefit many people worldwide. Models bring advantages and disadvantages to TBI research. They are good at representing one observable aspect but must ignore other aspects. For example, a researcher may study blunt impacts with a neuronal cell culture model that is the depth of the cortical layer. The researcher subjects this to different impact sizes, shapes, and forces to see how cells react and what cytokines they release. This model works well for the cortical layer, but ignores deeper cell layers due to the inability to oxygenate a deeper cell culture effectively. In this experiment, the disadvantage and limitation of this model is cell depth. It gathers accurate information within the cortical layer, but ignores interactions that might occur below the cortical layer. (en)
prov:wasDerivedFrom	wikipedia-en:Traumatic_brain_injury_modeling?oldid=1064795444&ns=0
page length (characters) of wiki page	17660 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Traumatic_brain_injury_modeling
is foaf:primaryTopic of	wikipedia-en:Traumatic_brain_injury_modeling

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