Type III hypersensitivity, in the Gell and Coombs classification of allergic reactions, occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes. There are three steps that lead to this response. The first step is immune complex formation, which involves the binding of antigens to antibodies to form mobile immune complexes. The second step is immune complex deposition, during which the complexes leave the plasma and are deposited into tissues. Finally, the third step is the inflammatory reaction, during which the classical pathway is activated and macrophages and neutrophils are recruited to the affected tissues. Such reactions may pro
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| - Hipersensibilidad de tipo III (es)
- Hipersensibilidade do tipo III (pt)
- Type III hypersensitivity (en)
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| - Una reacción de hipersensibilidad de tipo III ocurre cuando antígenos y anticuerpos (IgG o IgM) se encuentran presentes en grandes cantidades y en proporciones similares, causando reacciones de precipitación con entrecruzamiento muy extensas. (es)
- A hipersensibilidade de tipo III ocorre quando existe um acúmulo de imunocomplexos (complexos antígeno-anticorpo) que não foram depurados adequadamente pelas células imunes inatas, levando a um aumento da resposta inflamatória e atraindo leucócitos. Tais reações podem dar origem a doenças mediadas por imunocomplexos. (pt)
- Type III hypersensitivity, in the Gell and Coombs classification of allergic reactions, occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes. There are three steps that lead to this response. The first step is immune complex formation, which involves the binding of antigens to antibodies to form mobile immune complexes. The second step is immune complex deposition, during which the complexes leave the plasma and are deposited into tissues. Finally, the third step is the inflammatory reaction, during which the classical pathway is activated and macrophages and neutrophils are recruited to the affected tissues. Such reactions may pro (en)
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| - Type III hypersensitivity (en)
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| - Type III hypersensitivity (en)
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| - Una reacción de hipersensibilidad de tipo III ocurre cuando antígenos y anticuerpos (IgG o IgM) se encuentran presentes en grandes cantidades y en proporciones similares, causando reacciones de precipitación con entrecruzamiento muy extensas. (es)
- Type III hypersensitivity, in the Gell and Coombs classification of allergic reactions, occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes. There are three steps that lead to this response. The first step is immune complex formation, which involves the binding of antigens to antibodies to form mobile immune complexes. The second step is immune complex deposition, during which the complexes leave the plasma and are deposited into tissues. Finally, the third step is the inflammatory reaction, during which the classical pathway is activated and macrophages and neutrophils are recruited to the affected tissues. Such reactions may progress to immune complex diseases. (en)
- A hipersensibilidade de tipo III ocorre quando existe um acúmulo de imunocomplexos (complexos antígeno-anticorpo) que não foram depurados adequadamente pelas células imunes inatas, levando a um aumento da resposta inflamatória e atraindo leucócitos. Tais reações podem dar origem a doenças mediadas por imunocomplexos. (pt)
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