About: Type II secretion system

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The type 2 secretion system (often referred to as the type II secretion system or by the initials T2SS) is a type of protein secretion machinery found in various species of Gram-negative bacteria, including many human pathogens such as Pseudomonas aeruginosa and Vibrio cholerae. The type II secretion system is one of six protein secretory systems commonly found in Gram-negative bacteria, along with the type I, type III, and type IV secretion systems, as well as the chaperone/usher pathway, the autotransporter pathway/type V secretion system, and the type VI secretion system (some bacteria also utilize the type VII secretion system). Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes

Attributes	Values
rdf:type	Thing company Biomolecule Biomolecule Protein protein
rdfs:label	Sec-System (de) Sistem sekresi tipe II (in) Type II secretion system (en)
rdfs:comment	Das Sec-System ist ein Proteinkomplex und dient dem Transport von Proteinen über oder in die Zytoplasmamembran bei Bakterien und höheren Zellen. Es kommt bei den Typen II, IV und V der bakteriellen Proteinsekretion in Gram-negativen Bakterien vor. Es handelt sich um Transportproteine aus der Familie der Membran-ATPasen. Die Transportgleichung für Sec-Systeme lautet: ATP + pmf + Präprotein (Zytoplasma) ⇔ ADP + Pi + Präprotein (Periplasma oder Zytoplasmamembran) Der Begriff Sec-System ist abgeleitet von Sekretion. (de) Sistem sekresi tipe II atau tipe 2 (disingkat T2SS dalam bahasa Inggris) adalah suatu sistem sekresi protein yang terdapat dalam berbagai bakteri gram-negatif, termasuk berbagai patogen pada manusia, seperti Pseudomonas aeruginosa dan Vibrio cholerae. Sistem sekresi tipe II adalah satu dari enam jenis sistem sekresi protein yang umum ditemui pada bakteri gram-negatif. Seperti sistem-sistem lainnya, sistem sekresi tipe II membuka jalan bagi pemindahan protein sitoplasmik melintasi lipida dwilapis pada membran sel bakteri gram-negatif. (in) The type 2 secretion system (often referred to as the type II secretion system or by the initials T2SS) is a type of protein secretion machinery found in various species of Gram-negative bacteria, including many human pathogens such as Pseudomonas aeruginosa and Vibrio cholerae. The type II secretion system is one of six protein secretory systems commonly found in Gram-negative bacteria, along with the type I, type III, and type IV secretion systems, as well as the chaperone/usher pathway, the autotransporter pathway/type V secretion system, and the type VI secretion system (some bacteria also utilize the type VII secretion system). Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes (en)
name	Bacterial type II and III secretion system protein (en)
foaf:depiction
dcterms:subject	Bacteriology Secretion
Wikipage page ID	46231655 (xsd:integer)
Wikipage revision ID	1093520185 (xsd:integer)
Link from a Wikipage to another Wikipage	Catalyze Electric charge Nucleotide Beta barrel Hydrophilic Pathogens Cytoplasm Signal peptide Bacteriology Genome Oligomer Pseudomonas aeruginosa Vibrio cholerae Enzymes Genes Conserved sequence Operon Transmembrane proteins Protein subunit Twin-arginine translocation pathway Lipase Lipid bilayer Lipoprotein Gram-negative Adenosine triphosphate Amino acid Globular protein Gram-negative bacteria Protein domain Protease Quorum sensing Bacterial outer membrane Secretion Hydrolysis ATPase Chaperone-Usher fimbriae Binding domain Effector (biology) C-terminus Piston Hydrophobic Infection SecYEG Species Twitching motility Extracellular matrix Cell signalling Secretion Lipid bilayers N-terminus Microbial toxins Signal peptidase Pilin Periplasm Multiprotein complex Type VII secretion system Polymerize Type III secretion system Type IV pili dbr:Bacterial_inner_membrane dbr:Β-barrel_assembly_machinery
sameAs	Type II secretion system Type II secretion system Type II secretion system Type II secretion system Type II secretion system
TCDB	3 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Short_description dbt:Pfam_box
thumbnail	wiki-commons:Special:FilePath/T2SS.svg?width=300
InterPro	IPR004846 (en)
Pfam	PF00263 (en)
symbol	Secretin (en)
has abstract	Das Sec-System ist ein Proteinkomplex und dient dem Transport von Proteinen über oder in die Zytoplasmamembran bei Bakterien und höheren Zellen. Es kommt bei den Typen II, IV und V der bakteriellen Proteinsekretion in Gram-negativen Bakterien vor. Es handelt sich um Transportproteine aus der Familie der Membran-ATPasen. Man unterscheidet in cotranslationalen Proteintransport und posttranslationalen Proteintransport. Das Sec-System kann beide Transportformen durchführen, im Gegensatz zum Tat-System, welches nur posttranslational gefaltete Proteine transportiert. Es besteht aus einem Chaperon und einem Multiproteinkomplex, der als Translokase dient. Das als Chaperon wirkende SecB-Protein bindet an das neu synthetisierte Protein und verhindert dessen vorzeitige Faltung. Der Transportmotor SecA erkennt die Signalsequenz, bringt das Protein an den Translocator aus SecY, SecE, SecG, SecD und SecF und liefert durch ATP-Hydrolyse die Energie für den Transfer über die Membran. Die Transportgleichung für Sec-Systeme lautet: ATP + pmf + Präprotein (Zytoplasma) ⇔ ADP + Pi + Präprotein (Periplasma oder Zytoplasmamembran) Der Begriff Sec-System ist abgeleitet von Sekretion. (de) Sistem sekresi tipe II atau tipe 2 (disingkat T2SS dalam bahasa Inggris) adalah suatu sistem sekresi protein yang terdapat dalam berbagai bakteri gram-negatif, termasuk berbagai patogen pada manusia, seperti Pseudomonas aeruginosa dan Vibrio cholerae. Sistem sekresi tipe II adalah satu dari enam jenis sistem sekresi protein yang umum ditemui pada bakteri gram-negatif. Seperti sistem-sistem lainnya, sistem sekresi tipe II membuka jalan bagi pemindahan protein sitoplasmik melintasi lipida dwilapis pada membran sel bakteri gram-negatif. Sistem ini terdiri dari dua tahap. Tahap pertama menggunakan jalur sekresi Sec dan yang memindahkan protein melintasi membran dalam menuju periplasma. Setelah protein yang disekresikan berada di periplasma, terjadilah tahap kedua dan protein tersebut dikeluarkan dari sel. (in) The type 2 secretion system (often referred to as the type II secretion system or by the initials T2SS) is a type of protein secretion machinery found in various species of Gram-negative bacteria, including many human pathogens such as Pseudomonas aeruginosa and Vibrio cholerae. The type II secretion system is one of six protein secretory systems commonly found in Gram-negative bacteria, along with the type I, type III, and type IV secretion systems, as well as the chaperone/usher pathway, the autotransporter pathway/type V secretion system, and the type VI secretion system (some bacteria also utilize the type VII secretion system). Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes of Gram-negative bacteria. Secretion of proteins and effector molecules out of the cell plays a critical role in signaling other cells and in the invasion and parasitism of host cells. (en)
Membranome superfamily	430 (xsd:integer)
OPM family	348 (xsd:integer)

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