U.S. Highway 178 (US 178) is a spur of U.S. Highway 78. It currently runs for 240.49 miles (387.03 km) from Dorchester, South Carolina, at U.S. Highway 78 to Rosman, North Carolina, at U.S. Highway 64. It passes through the states of South Carolina and North Carolina. It goes through the cities of Pickens, Anderson, North, Orangeburg, Harleyville, South Carolina and Bowman, South Carolina.