In the U.S. state of Virginia, U.S. Route 220 (US 220) is a major north-south state highway that extends from the North Carolina state line through Roanoke to the West Virginia state line. South of Roanoke, US 220 is a four-lane highway within the proposed Interstate 73 (I-73) corridor. US 220 narrows to two lanes north of Roanoke, connecting to I-64 near Clifton Forge and then paralleling the Appalachian Mountains north-northeasterly in the direction of Cumberland, Maryland.