U.S. Route 35 (US 35) is a United States Highway that runs southeast-northwest for approximately 412 miles (663 km) from the western suburbs of Charleston, West Virginia to northern Indiana. Although the highway is physically southeast-northwest, it is nominally north–south. The highway's southern terminus is in Teays Valley, West Virginia, near Scott Depot, at Interstate 64 (I-64). Its northern terminus is near Michigan City, Indiana, at US 20. The West Virginia portion of the highway is mostly expressway, becoming a freeway shortly before it crosses the Ohio River into Ohio. The Ohio portion has been upgraded to a four-lane highway/freeway between the West Virginia state line and Trotwood, west of Dayton.