U.S. Route 52 (US 52) in the state of Illinois, is a surface road that traverses the north central and eastern portions of the state. It runs from the Dale Gardner Veterans Memorial Bridge over the Mississippi River between Sabula, Iowa, and Savanna with Illinois Route 64 (IL 64) southeast to the Indiana state line near Sheldon with US 24. This is a distance of 215.78 miles (347.26 km).