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Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS).

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  • UCP2 (ca)
  • UCP2 (it)
  • UCP2 (en)
  • UCP2 (uk)
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  • UCP2 (proteïna desacobladora 2) és una proteïna membre de la família de d'anions localitzats a la membrana mitocondrial interna com també ho és el transportador de fosfat inorgànic, entre altres. El seu nom es deu a l'elevada homologia d'aquesta proteïna amb UCP1 o termogenina com és el cas d'UCP3 i les altres UCPs. A diferència d'UCP1, d'expressió restringida a teixit adipós marró, l'expressió d'UCP2 és ubíqua i no intervé en la termogènesi adaptativa com ho fa UCP1. Com passa amb UCP3, UCP4 i BMCP1 la seva funció és però encara desconeguda. (ca)
  • UCP2 (англ. Uncoupling protein 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 309 амінокислот, а молекулярна маса — 33 229. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі, як транспорт. Локалізований у внутрішній мембрані мітохондрії. (uk)
  • Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS). (en)
  • La UCP2 o proteina di disaccoppiamento mitocondriale 2 è una proteina disaccoppiante che negli esseri umani è codificata dal gene UCP2. Questa proteina fa parte della famiglia dei degli anioni localizzati nella membrana mitocondriale interna come il vettore per il fosfato inorganico e del Ca2+ citosolico e non solo. Il suo nome è dovuto alla elevata omologia di questa proteina con UCP1 o termogenina. (it)
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  • UCP2 (proteïna desacobladora 2) és una proteïna membre de la família de d'anions localitzats a la membrana mitocondrial interna com també ho és el transportador de fosfat inorgànic, entre altres. El seu nom es deu a l'elevada homologia d'aquesta proteïna amb UCP1 o termogenina com és el cas d'UCP3 i les altres UCPs. A diferència d'UCP1, d'expressió restringida a teixit adipós marró, l'expressió d'UCP2 és ubíqua i no intervé en la termogènesi adaptativa com ho fa UCP1. Com passa amb UCP3, UCP4 i BMCP1 la seva funció és però encara desconeguda. (ca)
  • Mitochondrial uncoupling protein 2 is a protein that in humans is encoded by the UCP2 gene. Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells, which reduces production of reactive oxygen species (ROS). In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2 is expressed on many different tissues including the kidney, liver, GI tract, brain, and skeletal muscle. The exact mechanisms of anion transfer by UCPs are not known. UCPs contain the three homologous protein domains of MACPs. Although it was originally thought to play a role in non-shivering thermogenesis, obesity, diabetes and atherosclerosis, it now appears that the main function of UCP2 is the control of mitochondria-derived reactive oxygen species. Chromosomal order is 5'-UCP3-UCP2-3'. (en)
  • La UCP2 o proteina di disaccoppiamento mitocondriale 2 è una proteina disaccoppiante che negli esseri umani è codificata dal gene UCP2. Questa proteina fa parte della famiglia dei degli anioni localizzati nella membrana mitocondriale interna come il vettore per il fosfato inorganico e del Ca2+ citosolico e non solo. Il suo nome è dovuto alla elevata omologia di questa proteina con UCP1 o termogenina. A differenza dell'UCP1, che agisce solo sul grasso bruno e quindi solo sulla termogenesi adattativa, la UCP2 non interviene in questo meccanismo; sembra invece che questa intervenga nel controllo mitocondriale dei derivati delle specie reattive dell'ossigeno (ROS). (it)
  • UCP2 (англ. Uncoupling protein 2) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми. Довжина поліпептидного ланцюга білка становить 309 амінокислот, а молекулярна маса — 33 229. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинI: ІзолейцинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: ТреонінV: ВалінW: Триптофан Y: Тирозин Задіяний у такому біологічному процесі, як транспорт. Локалізований у внутрішній мембрані мітохондрії. (uk)
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