About: URB597

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URB597 (KDS-4103) is a relatively selective and irreversible inhibitor of the enzyme fatty acid amide hydrolase (FAAH). FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 has been found to elevate anandamide levels and have activity against neuropathic pain in a mouse model. URB597 was at one point being developed by Kadmus Pharmaceuticals, Inc. for clinical trials in humans.

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rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound yago:WikicatCarbamates yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Carbamate114792281 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Element114840755 yago:Formula106816935 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:Part113809207 yago:PhysicalEntity100001930 yago:Quintessence114847103 yago:Relation100031921 chemical compound yago:Salt115010703 yago:Statement106722453 yago:Substance100019613 yago:WikicatPhenolEthers
rdfs:label	URB597 (en)
rdfs:comment	URB597 (KDS-4103) is a relatively selective and irreversible inhibitor of the enzyme fatty acid amide hydrolase (FAAH). FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 has been found to elevate anandamide levels and have activity against neuropathic pain in a mouse model. URB597 was at one point being developed by Kadmus Pharmaceuticals, Inc. for clinical trials in humans. (en)
foaf:depiction
dcterms:subject	Biphenyls Carbamates Cyclohexyl compounds Antidepressants Benzamides Phenol esters Endocannabinoid reuptake inhibitors
Wikipage page ID	3755370 (xsd:integer)
Wikipage revision ID	1119175390 (xsd:integer)
Link from a Wikipage to another Wikipage	Cannabinoid receptor Mouse model Human Biphenyls Carbamates Cyclohexyl compounds Nature (journal) Neuropathic pain dbr:Brain-derived_neurotrophic_factor Laboratory rat Clinical trial Fatty acid amide hydrolase Peripheral nervous system Addiction medicine Anandamide 4-Nonylphenylboronic acid Antidepressants Benzamides Phenol esters PF-04457845 Central nervous system Hippocampus Endocannabinoid Prefrontal cortex Endocannabinoid reuptake inhibitors LY-2183240 FAAH Kadmus Pharmaceuticals, Inc.
Link from a Wikipage to an external page	http://www.nature.com/nm/journal/v9/n1/full/nm803.html
sameAs	URB597 URB597 URB597 URB597 URB597 URB597 URB597 URB597
dbp:wikiPageUsesTemplate	dbt:Cannabinoidergics dbt:Cannabinoids dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite
thumbnail	wiki-commons:Special:FilePath/URB597.svg?width=300
ImageFile	URB597.svg (en)
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has abstract	URB597 (KDS-4103) is a relatively selective and irreversible inhibitor of the enzyme fatty acid amide hydrolase (FAAH). FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 has been found to elevate anandamide levels and have activity against neuropathic pain in a mouse model. Preclinical studies have shown FAAH inhibitors to increase BDNF levels in the hippocampus and prefrontal cortex, highlighting their potential in addiction treatment as "enviromimetics". Indeed, Chauvet et al. found that chronic URB597 administration in rats "significantly reduces cocaine-seeking behaviour and cue- and stress-induced relapse". URB597 was at one point being developed by Kadmus Pharmaceuticals, Inc. for clinical trials in humans. (en)
prov:wasDerivedFrom	wikipedia-en:URB597?oldid=1119175390&ns=0
page length (characters) of wiki page	6420 (xsd:nonNegativeInteger)
IUPAC name	3′-Carbamoyl[1,1′-biphenyl]-3-yl cyclohexylcarbamate (en)
foaf:isPrimaryTopicOf	wikipedia-en:URB597
is Link from a Wikipage to another Wikipage of	Psychoactive drug List of psychedelic drugs

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