USS De Soto was a fast wooden-hulled sidewheel steamship that saw service as a U.S. Navy gunboat during the American Civil War. De Soto was originally a privately owned vessel, built for passenger service between New York and New Orleans. With the outbreak of the Civil War in 1861, she was purchased by the Navy, commissioned as USS De Soto, and sent to assist with the blockade of Confederate ports. De Soto's speed made her an effective pursuit ship, and she would capture or bring about the destruction of a total of eighteen blockade runners during the war.