USS Pillsbury (DD-227) was a Clemson-class destroyer of the United States Navy that served during World War II and the first of two ships named after John E. Pillsbury, a Rear Admiral in the United States Navy. She was sunk by Japanese cruisers, approximately 200 miles east of Christmas Island on or around 2 March 1942 with all hands, one of two major American surface warships lost in World War II with no survivors.