USS S-48 (SS-159) was the first submarine in the fourth group of S-class submarines of the United States Navy. S-48 was one of only five submarines — along with USS S-14 (SS-119), USS S-15 (SS-120), USS S-16 (SS-121). and USS S-17 (SS-122) — built by the Lake Torpedo Boat Company to see service in World War II. She was the second-to-last of them to be decommissioned.