USS Wyalusing was a double-ended, side-wheel gunboat that served in the United States Navy during the American Civil War. She was named for the borough of Wyalusing in Bradford County, Pennsylvania. Wyalusing was built at Philadelphia by C. H. & W. H. Cramp, launched on 12 May 1863, and commissioned at the Philadelphia Navy Yard on 8 February 1864, with Lieutenant Commander in command.