UV-B resistance 8 (UVR8) also known as ultraviolet-B receptor UVR8 is an UV-B – sensing protein found in plants and possibly other sources. It is responsible for sensing ultraviolet light in the range 280-315 nm and initiating the plant stress response. It is most sensitive at 285nm, near the lower limit of UVB. UVR8 was first identified as a crucial mediator of a plant's response to UV-B in Arabidopsis thaliana containing a mutation in this protein. This plant was found to have a hypersensitivity to UV-B which damages DNA. UVR8 is thought to be a unique photoreceptor as it doesn't contain a prosthetic chromophore but its light-sensing ability is intrinsic to the molecule. Tryptophan (Trp) residue 285 has been suggested to act the UV-B sensor, while other Trp residues have been also seen t
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| - UV-B RESISTANCE LOCUS 8 (UVR8)は、植物において紫外線のうちUV-Bの受容体としてはたらくタンパク質である。波長280-315 nmの紫外線を受容して、植物のストレス応答を開始する役割を担っている。UV-Bの下限波長に近い波長285 nmで最も感度が高い。UVR8は植物のUV-B応答における必須の調節因子として、モデル植物のシロイヌナズナArabidopsis thaliana において初めて同定された。この時、UVR8に突然変異が起きたシロイヌナズナでは、UV-BによるDNA損傷の影響を受けやすいことが発見された。植物における他の光受容体と異なるUVR8の特徴として、発色団となる補助的な小分子を必要とせず、タンパク質自体に光受容の能力が備わっていることが挙げられる。タンパク質中に存在する3つ組のトリプトファン残基が発色団としてUV-Bセンサーの機能を果たしていると考えられている。 (ja)
- UV-B resistance 8 (UVR8) also known as ultraviolet-B receptor UVR8 is an UV-B – sensing protein found in plants and possibly other sources. It is responsible for sensing ultraviolet light in the range 280-315 nm and initiating the plant stress response. It is most sensitive at 285nm, near the lower limit of UVB. UVR8 was first identified as a crucial mediator of a plant's response to UV-B in Arabidopsis thaliana containing a mutation in this protein. This plant was found to have a hypersensitivity to UV-B which damages DNA. UVR8 is thought to be a unique photoreceptor as it doesn't contain a prosthetic chromophore but its light-sensing ability is intrinsic to the molecule. Tryptophan (Trp) residue 285 has been suggested to act the UV-B sensor, while other Trp residues have been also seen t (en)
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| - UVB-resistance protein UVR8 (en)
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| - Crystal structure of UVB-resistance protein UVR8. (en)
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| - Arabidopsis thaliana (en)
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| - UV-B resistance 8 (UVR8) also known as ultraviolet-B receptor UVR8 is an UV-B – sensing protein found in plants and possibly other sources. It is responsible for sensing ultraviolet light in the range 280-315 nm and initiating the plant stress response. It is most sensitive at 285nm, near the lower limit of UVB. UVR8 was first identified as a crucial mediator of a plant's response to UV-B in Arabidopsis thaliana containing a mutation in this protein. This plant was found to have a hypersensitivity to UV-B which damages DNA. UVR8 is thought to be a unique photoreceptor as it doesn't contain a prosthetic chromophore but its light-sensing ability is intrinsic to the molecule. Tryptophan (Trp) residue 285 has been suggested to act the UV-B sensor, while other Trp residues have been also seen to be involved (Trp233 > Trp337 > Trp94) although in-vivo data suggests that Trp285 and Trp233 are most important. (en)
- UV-B RESISTANCE LOCUS 8 (UVR8)は、植物において紫外線のうちUV-Bの受容体としてはたらくタンパク質である。波長280-315 nmの紫外線を受容して、植物のストレス応答を開始する役割を担っている。UV-Bの下限波長に近い波長285 nmで最も感度が高い。UVR8は植物のUV-B応答における必須の調節因子として、モデル植物のシロイヌナズナArabidopsis thaliana において初めて同定された。この時、UVR8に突然変異が起きたシロイヌナズナでは、UV-BによるDNA損傷の影響を受けやすいことが発見された。植物における他の光受容体と異なるUVR8の特徴として、発色団となる補助的な小分子を必要とせず、タンパク質自体に光受容の能力が備わっていることが挙げられる。タンパク質中に存在する3つ組のトリプトファン残基が発色団としてUV-Bセンサーの機能を果たしていると考えられている。 (ja)
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