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About: Uncoupling (neuropsychopharmacology)     Goto   Sponge   NotDistinct   Permalink

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In neuropsychopharmacology, uncoupling, also known as decoupling, is the process of receptor- or ligand-binding sites or domains becoming separated, moving alignments and/or becoming internalised as a result of drug tolerance resulting from prolonged exposure to bioavailable psychoactive substances or toxins.