Ventura Boulevard is one of the primary east–west thoroughfares in the San Fernando Valley region of the City of Los Angeles, California. Ventura Boulevard is one of the oldest routes in the San Fernando Valley as it was originally a part of the Camino Real (the trail between Spanish missions). It was also U.S. Route 101 (US 101) before the freeway (which it parallels for much of Ventura Boulevard's length) was built, and it was also previously signed as U.S. Route 101 Business (US 101 Bus.).