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About: Vibralactone     Goto   Sponge   NotDistinct   Permalink

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Vibralactones are a group of related terpenoid chemical compounds, the first of which were isolated from the Basidiomycete in 2006. Additional vibralactones have also been isolated from the fungus Stereum hirsutum. Vibralactone A has attracted research interest because it is an inhibitor of pancreatic lipase (IC50 0.4 μg/mL) with in vitro activity comparable to that of the obesity drug orlistat. Several laboratory syntheses of vibralactone A have been developed.