State Route 280 (SR 280) is a primary state highway in the U.S. state of Virginia. The highway runs 5.0 miles (8.0 km) from SR 42 in Harrisonburg east to U.S. Route 33 (US 33) in Massanetta Springs in central Rockingham County. SR 280 is a four-lane southern bypass of Harrisonburg that connects SR 42 and US 33 with US 11 and SR 253 outside of the city core.