About: Visilizumab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Unit109465459, within Data Space : dbpedia.demo.openlinksw.com associated with source document(s)
QRcode icon
http://dbpedia.demo.openlinksw.com/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FVisilizumab&invfp=IFP_OFF&sas=SAME_AS_OFF

Visilizumab (tentative trade name Nuvion, PDL BioPharma Inc.) is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease. Visilizumab binds to the CD3 receptor on certain activated T cells without affecting resting T cells. It is currently under clinical studies for the treatment of ulcerative colitis and Crohn's disease. Visilizumab has also been radiolabelled with technetium-99m for imaging T cells.

AttributesValues
rdf:type
rdfs:label
  • Wizylizumab (pl)
  • Visilizumab (en)
rdfs:comment
  • Visilizumab (tentative trade name Nuvion, PDL BioPharma Inc.) is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease. Visilizumab binds to the CD3 receptor on certain activated T cells without affecting resting T cells. It is currently under clinical studies for the treatment of ulcerative colitis and Crohn's disease. Visilizumab has also been radiolabelled with technetium-99m for imaging T cells. (en)
  • Wizylizumab (łac. visilizumabum, ang. visilizumab) - lek immunosupresyjny, syntetyczne białko, humanizowane przeciwciała monoklonalne przeciw limfocytom CD3. Wykazuje swoiste działanie immunosupresyjne, poprzez indukowanie procesu apoptozy aktywowanych limfocytów T i hamowanie receptora chemokin CXCR3. Jest lekiem stosowanym dożylnie. Podejmuje się próby stosowania wizylizumabu w chorobach zapalnych jelit (wrzodziejące zapalenie jelita grubego i choroba Leśniowskiego-Crohna) - prowadzone są obecnie badania kliniczne. Lek był również badany w kierunku wykorzystania w leczeniu ostrej choroby "przeszczep przeciw gospodarzowi" opornej na terapię kortykosteroidami. (pl)
dcterms:subject
Wikipage page ID
Wikipage revision ID
Link from a Wikipage to another Wikipage
sameAs
dbp:wikiPageUsesTemplate
ATC prefix
  • none (en)
CAS number
ChEMBL
ChemSpiderID
  • none (en)
DrugBank
  • DB12053 (en)
KEGG
  • D06314 (en)
source
  • zu/o (en)
target
type
  • mab (en)
UNII
  • H18SKU3289 (en)
verifiedrevid
has abstract
  • Visilizumab (tentative trade name Nuvion, PDL BioPharma Inc.) is a humanized monoclonal antibody. It is being investigated for use as an immunosuppressive drug in patients with ulcerative colitis and Crohn's disease. Visilizumab binds to the CD3 receptor on certain activated T cells without affecting resting T cells. It is currently under clinical studies for the treatment of ulcerative colitis and Crohn's disease. PDL BioPharma, Inc. canceled production of visilizumab following its Phase II/III clinical trials, citing its inefficacy and poor safety profile compared to other drugs on the market as the major reasons. Nevertheless, clinical trials continue for various diseases like multiple myeloma and diabetes mellitus type 1 as of July 2009. Visilizumab has also been radiolabelled with technetium-99m for imaging T cells. (en)
  • Wizylizumab (łac. visilizumabum, ang. visilizumab) - lek immunosupresyjny, syntetyczne białko, humanizowane przeciwciała monoklonalne przeciw limfocytom CD3. Wykazuje swoiste działanie immunosupresyjne, poprzez indukowanie procesu apoptozy aktywowanych limfocytów T i hamowanie receptora chemokin CXCR3. Jest lekiem stosowanym dożylnie. Podejmuje się próby stosowania wizylizumabu w chorobach zapalnych jelit (wrzodziejące zapalenie jelita grubego i choroba Leśniowskiego-Crohna) - prowadzone są obecnie badania kliniczne. Lek był również badany w kierunku wykorzystania w leczeniu ostrej choroby "przeszczep przeciw gospodarzowi" opornej na terapię kortykosteroidami. Lek jest zarejestrowany pod nazwą handlową Nuvion. (pl)
mab type
  • mab (en)
gold:hypernym
prov:wasDerivedFrom
page length (characters) of wiki page
CAS number
  • 219716-33-3
ChEMBL
  • 2108811
DrugBank
  • DB12053
FDA UNII code
  • H18SKU3289
KEGG
  • D06314
foaf:isPrimaryTopicOf
is Link from a Wikipage to another Wikipage of
is Wikipage redirect of
is foaf:primaryTopic of
Faceted Search & Find service v1.17_git139 as of Feb 29 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (378 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software