About: Vpu protein

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Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. Vpu-mediated CD4 degradation is thought to prevent CD4-Env binding in the endoplasmic reticulum to facilitate proper Env assembly into virions. It is found in the membranes of infected cells, but not the virus particles themselves.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	Vpu protein (en)
rdfs:comment	Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. Vpu-mediated CD4 degradation is thought to prevent CD4-Env binding in the endoplasmic reticulum to facilitate proper Env assembly into virions. It is found in the membranes of infected cells, but not the virus particles themselves. (en)
name	Vpu (en) Viral Protein Unique (en)
foaf:depiction
dcterms:subject	HIV/AIDS Protein domains Viral regulatory and accessory proteins
Wikipage page ID	17707387 (xsd:integer)
Wikipage revision ID	1102328334 (xsd:integer)
Link from a Wikipage to another Wikipage	BST2 Proteasome Endoplasmic reticulum Messenger RNA Model lipid bilayer C-terminal Virion Integral membrane protein NMR spectroscopy Env (gene) Gene Simian immunodeficiency virus Cell (biology) HIV Cytoplasmic Ion channel Lipid raft Alpha helix HIV/AIDS Cell membrane Glycosylphosphatidylinositol Protein domains Viral regulatory and accessory proteins dbr:CD4 Interferon Casein kinase 2 Xenopus dbr:Tetherin Ribosome Transmembrane domain N-terminus Viral life cycle Phosphorylation Structure and genome of HIV Initiation codon Viroporin Accessory protein Glycosylated E3 ubiquitin ligase Oligomeric protein Type I membrane protein
sameAs	Vpu protein Vpu protein Vpu protein
TCDB	1 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Infobox_nonhuman_protein dbt:Infobox_protein_family dbt:InterPro_content dbt:MeshName dbt:Other_uses_of dbt:Reflist dbt:Sub dbt:Viral_proteins
thumbnail	wiki-commons:Special:FilePath/PDB_1pje_EBI.jpg?width=300
SCOP	1 (xsd:integer)
caption	structure of the channel-forming trans-membrane domain of virus protein "u" from HIV-1 (en)
InterPro	IPR008187 (en)
Organism	HIV-1 (en)
Pfam	PF00558 (en)
symbol	Vpu (en) vpu (en)
taxId	11676 (xsd:integer)
UniProt	P05919 (en)
has abstract	Vpu is an accessory protein that in HIV is encoded by the vpu gene. Vpu stands for "Viral Protein U". The Vpu protein acts in the degradation of CD4 in the endoplasmic reticulum and in the enhancement of virion release from the plasma membrane of infected cells. Vpu induces the degradation of the CD4 viral receptor and therefore participates in the general downregulation of CD4 expression during the course of HIV infection. Vpu-mediated CD4 degradation is thought to prevent CD4-Env binding in the endoplasmic reticulum to facilitate proper Env assembly into virions. It is found in the membranes of infected cells, but not the virus particles themselves. The Vpu gene is found exclusively in HIV-1 and some HIV-1-related simian immunodeficiency virus (SIV) isolates, such as SIVcpz, SIVgsn, and SIVmon, but not in HIV-2 or the majority of SIV isolates. Structural similarities between Vpu and another small viral protein, M2, encoded by influenza A virus were first noted soon after the discovery of Vpu. Since then, Vpu has been shown to form cation-selective ion channels when expressed in Xenopus oocytes or mammalian cells and also when purified and reconstituted into planar lipid bilayers. Vpu also permeabilizes membranes of bacteria and mammalian cells to small molecules. Therefore, it is considered a member of the Viroporins family. (en)
Chromosome	viral genome (en)
EntrezChromosome	NC_001802.1 (en)
EntrezGene	155945 (xsd:integer)
GenLoc end	5892 (xsd:integer)
GenLoc start	5570 (xsd:integer)
OPM family	262 (xsd:integer)
OPM protein	2.209032E8 (second)
RefSeqProtein	NP_057855.1 (en)
prov:wasDerivedFrom	wikipedia-en:Vpu_protein?oldid=1102328334&ns=0
page length (characters) of wiki page	11538 (xsd:nonNegativeInteger)
Symbol	Vpu
foaf:isPrimaryTopicOf	wikipedia-en:Vpu_protein
is Link from a Wikipage to another Wikipage of	Biotron Limited Host switch Vpu Lentivirus Viral protein U Immunoevasin Transporter Classification Database
is Wikipage redirect of	Vpu Viral protein U

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