The women's tournament of the water polo at the 2022 South American Games was held from 11 to 15 October 2022 at the Centro Acuático Nacional in Asunción, Paraguay. It was the second edition of the water polo women's tournament at the South American Games since its first appareance in (it was not held in Santiago 2014 and ended being cancelled in Cochabamba 2018). The tournament served as qualifier for the 2023 Pan American Games, with the top two teams qualifiyng to the . beat Venezuela 18–17 (4–3 on penalties) to win the bronze medal.