The Wayne State University historic district consists of three buildings on 4735-4841 Cass Avenue in Midtown Detroit, Michigan: the Mackenzie House (4735 Cass), Hilberry Theatre (4743 Cass), and Old Main (4841 Cass), all on the campus of Wayne State University. The buildings were designated a Michigan State Historic Site in 1957 and listed on the National Register of Historic Places in 1978.