The wide dynamic range (WDR) neuron was first discovered by Mendell in 1966. Early studies of this neuron established what is known as the gate control theory of pain. The basic concept is that non-painful stimuli block the pathways for painful stimuli, inhibiting possible painful responses. This theory was supported by the fact that WDR neurons are responsible for responses to both painful and non-painful stimuli, and the idea that these neurons couldn't produce more than one of these responses simultaneously. WDR neurons respond to all types of somatosensory stimuli, make up the majority of the neurons found in the posterior grey column, and have the ability to produce long range responses including those responsible for pain and itch.
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| - WDR-Neuron (de)
- Neuronas de rango dinámico amplio (es)
- Wide dynamic range neuron (en)
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| - WDR-Neurone (Wide-dynamic-range-Neurone) sind Neurone, die mit geringer Entladungsfrequenz auf nicht-noxische Reize (beispielsweise Druck) reagieren. Sie haben grundsätzlich einen afferenten Eingang nicht nur von Nozizeptoren, sondern auch von niederschwelligen Mechanorezeptoren. Es gibt Hinweise darauf, dass WDR-Neuronen auch an der Entstehung des Schmerzgedächtnisses beteiligt sind. (de)
- Neuronas de rango dinámico amplio están situadas profundamente en el asta dorsal, preferentemente en la lámina V, que se proyectan hacia el tálamo por medio del tracto espinotalámico y que alcanzan la corteza sensorial primaria. En la teoría se le han intentado propugnar diversas funciones dentro del sistema nervioso somatosensorial. Se consideraba que su funcionamiento de por sí podría justificar la sensación de dolor, sin embargo podrían conllevar un fenómeno de hiperalgesia. Responden tanto a estímulos nocivos como no nocivos provenientes de fibras Aβ. Sirven para diferenciar la intensidad de dolor. (es)
- The wide dynamic range (WDR) neuron was first discovered by Mendell in 1966. Early studies of this neuron established what is known as the gate control theory of pain. The basic concept is that non-painful stimuli block the pathways for painful stimuli, inhibiting possible painful responses. This theory was supported by the fact that WDR neurons are responsible for responses to both painful and non-painful stimuli, and the idea that these neurons couldn't produce more than one of these responses simultaneously. WDR neurons respond to all types of somatosensory stimuli, make up the majority of the neurons found in the posterior grey column, and have the ability to produce long range responses including those responsible for pain and itch. (en)
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| - WDR-Neurone (Wide-dynamic-range-Neurone) sind Neurone, die mit geringer Entladungsfrequenz auf nicht-noxische Reize (beispielsweise Druck) reagieren. Sie haben grundsätzlich einen afferenten Eingang nicht nur von Nozizeptoren, sondern auch von niederschwelligen Mechanorezeptoren. Es gibt Hinweise darauf, dass WDR-Neuronen auch an der Entstehung des Schmerzgedächtnisses beteiligt sind. (de)
- Neuronas de rango dinámico amplio están situadas profundamente en el asta dorsal, preferentemente en la lámina V, que se proyectan hacia el tálamo por medio del tracto espinotalámico y que alcanzan la corteza sensorial primaria. En la teoría se le han intentado propugnar diversas funciones dentro del sistema nervioso somatosensorial. Se consideraba que su funcionamiento de por sí podría justificar la sensación de dolor, sin embargo podrían conllevar un fenómeno de hiperalgesia. Responden tanto a estímulos nocivos como no nocivos provenientes de fibras Aβ. Sirven para diferenciar la intensidad de dolor. (es)
- The wide dynamic range (WDR) neuron was first discovered by Mendell in 1966. Early studies of this neuron established what is known as the gate control theory of pain. The basic concept is that non-painful stimuli block the pathways for painful stimuli, inhibiting possible painful responses. This theory was supported by the fact that WDR neurons are responsible for responses to both painful and non-painful stimuli, and the idea that these neurons couldn't produce more than one of these responses simultaneously. WDR neurons respond to all types of somatosensory stimuli, make up the majority of the neurons found in the posterior grey column, and have the ability to produce long range responses including those responsible for pain and itch. (en)
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