William F. Russell (c.1805 – after 1875) was a Florida settler, soldier, and member of the Florida House of Representatives, serving as Speaker of the House in 1854. Russell was born in North Carolina. He became a major, and was put in charge of the Indian River Settlement in St. Lucia County, which broke up following an attack by Seminole Indians in July 1849. Russell was shot in the arm during the attack. Russell's brother-in-law John Barker was killed, but the rest of his family escaped to New Smyrna.