William H. Wisener (April 22, 1812 – December 24, 1882) was an American politician, active primarily at the state level in Tennessee during the mid-19th century. He served four terms in the Tennessee House of Representatives (1847–1849, 1851–1855, and 1859–1861), including one term as Speaker (1853–1855). A Southern Unionist, he led the opposition to secession in the House on the eve of the Civil War. After the war, he served in the Tennessee Senate, where he introduced the 13th Amendment for ratification in April 1865.