William Manning Lowe (June 12, 1842 – October 12, 1882) was an American politician who served the state of Alabama in the U.S. House of Representatives between 1879 and 1881 and in 1882. He was born on June 12, 1842, in Huntsville, Alabama. He attended the Wesleyan University at Florence, Alabama and the University of Virginia. During the American Civil War he enlisted in the Confederate States Army, eventually rising to the rank of lieutenant colonel. He studied law, was admitted to the bar, and practiced in Huntsville. He was solicitor of the fifth judicial circuit between 1865 and 1867. In 1870, he was elected to the Alabama House of Representatives, and was a delegate to the Alabama constitutional convention of 1875.