Captain William Sayle (c. 1590–1671) was a prominent British landholder who was Governor of Bermuda in 1643 and again in 1658. As an Independent in religion and politics, and an adherent of Oliver Cromwell, he was dissatisfied with life in Bermuda, and so founded the company of the Eleutheran Adventurers who became the first settlers of the Bahamas between 1646 and 1648. He later became the first governor of colonial South Carolina from 1670 to 1671.