Route 42 is a major arterial road located in Winnipeg, Manitoba. It connects the suburbs of North Kildonan, East Kildonan, Fort Rouge, Fort Garry, and St. Norbert with the city's downtown core. In the north, it is a continuation of Manitoba Provincial Road 204 (PR 204); in the south, it is a continuation of PTH 75 (or Lord Selkirk Highway). The route is commonly known as Pembina Highway between PTH 75 to Donald Street; as the Disraeli Freeway between Main Street and Talbot Avenue; and as Henderson Highway from Talbot to PR 204.