State Trunk Highway 125 (often called Highway 125, STH-125 or WIS 125) is a 2.62-mile (4.22 km) state highway in Outagamie County in the US state of Wisconsin. It runs from Interstate 41 (i-41) in the Town of Grand Chute east to WIS 47 in Appleton; the route is located entirely within these two municipalities. WIS 125 is maintained by the Wisconsin Department of Transportation (WisDOT).