About: Yangonin

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Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), and selectivity vs. the CB2 receptor (Ki >10 μM) where it behaves as an agonist. The CB1 receptor affinity of yangonin suggests that the endocannabinoid system might contribute to the complex human psychopharmacology of the traditional kava drink and the anxiolytic preparations obtained from the kava plant.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Chemical compound yago:WikicatAnalgesics yago:WikicatAnxiolytics yago:Agent114778436 yago:Analgesic102707683 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:Matter100020827 yago:Medicine103740161 yago:MinorTranquilizer103771443 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 chemical compound yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Substance100020090 yago:Tranquilizer104470232 umbel-rc:ChemicalSubstanceType
rdfs:label	ヤンゴニン (ja) Yangonin (en)
rdfs:comment	ヤンゴニン (Yangonin) は、カヴァに含まれる6つの主なカヴァラクトンのうちの1つである。に対する結合親和性 (Ki = 0.72 μM )を持ち、アゴニストとして作用する。 (ja) Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), and selectivity vs. the CB2 receptor (Ki >10 μM) where it behaves as an agonist. The CB1 receptor affinity of yangonin suggests that the endocannabinoid system might contribute to the complex human psychopharmacology of the traditional kava drink and the anxiolytic preparations obtained from the kava plant. (en)
foaf:depiction
dcterms:subject	Kavalactones Analgesics GABAA receptor positive allosteric modulators Phenol ethers Monoamine oxidase inhibitors CB1 receptor agonists
Wikipage page ID	24225422 (xsd:integer)
Wikipage revision ID	1099982923 (xsd:integer)
Link from a Wikipage to another Wikipage	Cannabinoid receptor Kavalactones In vitro Psychopharmacology Analgesics GABAA receptor positive allosteric modulators Phenol ethers dbr:Coumaroyl-CoA Endocannabinoid system Glutathione Monoamine oxidase Anxiolytic Apoptosis Malonyl-CoA Agonist Monoamine oxidase inhibitors Ethidium bromide Kava Kavalactone CB1 receptor agonists Biosynthesis Hepatocyte Necrosis Cannabinoid receptor type 1 Cannabinoid receptor type 2 Monoamine oxidase B
sameAs	Yangonin Yangonin Yangonin Yangonin Yangonin Yangonin Yangonin Yangonin Yangonin Yangonin
dbp:wikiPageUsesTemplate	dbt:Cannabinoidergics dbt:Chembox dbt:Chembox_Hazards dbt:Chembox_Identifiers dbt:Chembox_Properties dbt:Clear-left dbt:Cn dbt:Dopaminergics dbt:GABAAR_PAMs dbt:Reflist dbt:Cascite dbt:Chemspidercite dbt:Ebicite dbt:Fdacite dbt:Stdinchicite dbt:Kava
thumbnail	wiki-commons:Special:FilePath/Yangonin.svg?width=300
ImageFile	Yangonin.svg (en) Yangonin02.png (en)
imagesize	200 (xsd:integer)
PIN	4 (xsd:integer)
Verifiedfields	changed (en)
verifiedrevid	412605522 (xsd:integer)
Watchedfields	changed (en)
has abstract	Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess binding affinity for the cannabinoid receptor CB1 (Ki = 0.72 μM), and selectivity vs. the CB2 receptor (Ki >10 μM) where it behaves as an agonist. The CB1 receptor affinity of yangonin suggests that the endocannabinoid system might contribute to the complex human psychopharmacology of the traditional kava drink and the anxiolytic preparations obtained from the kava plant. Further in vitro studies have also demonstrated yangonin to be an inhibitor of monoamine oxidase, with a moderate preference for isozyme B, which could open the door to a wide range of interactions. (en) ヤンゴニン (Yangonin) は、カヴァに含まれる6つの主なカヴァラクトンのうちの1つである。に対する結合親和性 (Ki = 0.72 μM )を持ち、アゴニストとして作用する。 (ja)

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