Zerbe Run (also known as Zerbe Creek) is a tributary of Mahanoy Creek in Northumberland County, Pennsylvania, in the United States. It is approximately 8.3 miles (13.4 km) long and flows through Coal Township, Zerbe Township, and Little Mahanoy Township. The watershed of the stream has an area of 13.1 square miles (34 km2). Part of the stream is impaired by abandoned mine drainage, but its upper reaches are not impacted by mining. Several mine drainage discharges occur within the watershed. The stream is not far from the Western Middle Anthracite Field.