Gerald Patterson and Suzanne Lenglen were the defending champions, but Patterson did not participate. Lenglen partnered with André Gobert but they lost in the second round to eventual champions Randolph Lycett and Elizabeth Ryan. Lycett and Ryan defeated Max Woosnam and Phyllis Howkins in the final, 6–3, 6–1 to win the mixed doubles tennis title at the 1921 Wimbledon Championships.