The 1942 Kansas Jayhawks football team represented the University of Kansas in the Big Six Conference during the 1942 college football season. In their fourth and final season under head coach Gwinn Henry, the Jayhawks compiled a 2–8 record (1–4 against conference opponents), tied for fifth place in the conference, and were outscored by opponents by a combined total of 248 to 77. They played their home games at Memorial Stadium in Lawrence, Kansas.