The 1943 Kansas Jayhawks football team represented the University of Kansas in the Big Six Conference during the 1943 college football season. In their first season under head coach Henry Shenk, the Jayhawks compiled a 4–5–1 record (2–3 against conference opponents), tied for fourth place in the conference, and were outscored by opponents by a combined total of 107 to 96. They played their home games at Memorial Stadium in Lawrence, Kansas.