The 1950 Wyoming Cowboys football team represented the University of Wyoming in the Skyline Conference during the 1950 college football season. In their fourth season under head coach Bowden Wyatt, the Cowboys compiled a perfect 10–0 record (5–0 against Skyline opponents), won the Skyline Conference championship, ranked No. 12 in the final AP Poll, defeated Washington and Lee in the 1951 Gator Bowl, and outscored all opponents by a total of 363 to 59.