The 1987–88 Duke Blue Devils men's basketball team represented Duke University. The head coach was Mike Krzyzewski. The team played its home games in the Cameron Indoor Stadium in Durham, North Carolina, and was a member of the Atlantic Coast Conference. Duke earned its sixth Final Four appearance in the 1988 NCAA Division I men's basketball tournament, where they suffered a defeat from the Danny Manning-led Kansas Jayhawks by a score of 66-59.